اخطار‌های زیر رخ داد:
Warning [2] Undefined array key "extra" - Line: 100 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 100 errorHandler->error
/inc/plugins/google_seo.php 317 require_once
/inc/class_plugins.php 38 require_once
/inc/init.php 239 pluginSystem->load
/global.php 20 require_once
/showthread.php 28 require_once
Warning [2] Undefined array key "parent" - Line: 447 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 447 errorHandler->error
/inc/plugins/google_seo/url.php 1144 google_seo_url_create
/inc/plugins/google_seo/url.php 174 google_seo_url_hook
/inc/plugins/google_seo.php 317 require_once
/inc/class_plugins.php 38 require_once
/inc/init.php 239 pluginSystem->load
/global.php 20 require_once
/showthread.php 28 require_once
Warning [2] Undefined array key "pid" - Line: 1147 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 1147 errorHandler->error
/inc/plugins/google_seo/url.php 174 google_seo_url_hook
/inc/plugins/google_seo.php 317 require_once
/inc/class_plugins.php 38 require_once
/inc/init.php 239 pluginSystem->load
/global.php 20 require_once
/showthread.php 28 require_once
Warning [2] Trying to access array offset on value of type null - Line: 59 - File: inc/class_session.php PHP 8.2.4 (Linux)
File Line Function
/inc/class_session.php 59 errorHandler->error
/global.php 49 session->init
/showthread.php 28 require_once
Warning [2] Undefined array key "lockoutexpiry" - Line: 94 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 94 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined array key "pid" - Line: 129 - File: inc/plugins/google_seo/redirect.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/redirect.php 129 errorHandler->error
/inc/class_plugins.php 142 google_seo_redirect_hook
/global.php 100 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined array key "page" - Line: 144 - File: inc/plugins/google_seo/redirect.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/redirect.php 144 errorHandler->error
/inc/class_plugins.php 142 google_seo_redirect_hook
/global.php 100 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined array key "action" - Line: 145 - File: inc/plugins/google_seo/redirect.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/redirect.php 145 errorHandler->error
/inc/class_plugins.php 142 google_seo_redirect_hook
/global.php 100 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined array key "page" - Line: 151 - File: inc/plugins/google_seo/redirect.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/redirect.php 151 errorHandler->error
/inc/class_plugins.php 142 google_seo_redirect_hook
/global.php 100 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Constant IN_MYBB already defined - Line: 9 - File: affiliate.php PHP 8.2.4 (Linux)
File Line Function
[PHP]   errorHandler->error
/affiliate.php 9 define
/global.php 102 require_once
/showthread.php 28 require_once
Warning [2] Undefined variable $affiliate - Line: 44 - File: affiliate.php PHP 8.2.4 (Linux)
File Line Function
/affiliate.php 44 errorHandler->error
/global.php 102 require_once
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$today_rel - Line: 474 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 474 errorHandler->error
/global.php 476 my_date
/showthread.php 28 require_once
Warning [2] Undefined array key "lockoutexpiry" - Line: 555 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 555 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined array key "avatartype" - Line: 816 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 816 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined array key "avatartype" - Line: 816 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 816 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined variable $myalerts_js - Line: 104 - File: global.php(874) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(874) : eval()'d code 104 errorHandler->error
/global.php 874 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $awaitingusers - Line: 495 - File: global.php(877) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(877) : eval()'d code 495 errorHandler->error
/global.php 877 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $bam_announcements - Line: 497 - File: global.php(877) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(877) : eval()'d code 497 errorHandler->error
/global.php 877 eval
/showthread.php 28 require_once
Warning [2] Undefined array key "style" - Line: 942 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 942 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$lang_select_default - Line: 5211 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 5211 errorHandler->error
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_google_plus - Line: 18 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 18 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_facebook - Line: 19 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 19 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_twitter - Line: 20 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 20 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_pinterest - Line: 21 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 21 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $myalerts_modal - Line: 61 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 61 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $choosekq - Line: 785 - File: inc/plugins/changstats.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php 785 errorHandler->error
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $listtab - Line: 800 - File: inc/plugins/changstats.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php 800 errorHandler->error
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $chooselatestposts - Line: 3 - File: inc/plugins/changstats.php(801) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(801) : eval()'d code 3 errorHandler->error
/inc/plugins/changstats.php 801 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $choosetop_user - Line: 4 - File: inc/plugins/changstats.php(823) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(823) : eval()'d code 4 errorHandler->error
/inc/plugins/changstats.php 823 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $choosetop_forum - Line: 4 - File: inc/plugins/changstats.php(824) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(824) : eval()'d code 4 errorHandler->error
/inc/plugins/changstats.php 824 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $autorefresh - Line: 73 - File: inc/plugins/changstats.php(842) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(842) : eval()'d code 73 errorHandler->error
/inc/plugins/changstats.php 842 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined array key 3 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4486 get_forum_link
/inc/functions.php 4458 build_forum_breadcrumb
/showthread.php 454 build_forum_breadcrumb
Warning [2] Trying to access array offset on value of type null - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4486 get_forum_link
/inc/functions.php 4458 build_forum_breadcrumb
/showthread.php 454 build_forum_breadcrumb
Warning [2] Undefined array key 17 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4479 get_forum_link
/showthread.php 454 build_forum_breadcrumb
Warning [2] Undefined property: MyLanguage::$ratings_update_error - Line: 5 - File: showthread.php(768) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/showthread.php(768) : eval()'d code 5 errorHandler->error
/showthread.php 768 eval
Warning [2] Undefined array key 1 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions_post.php 251 get_profile_link
/showthread.php 1114 build_postbit
Warning [2] Trying to access array offset on value of type null - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions_post.php 251 get_profile_link
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions_user.php 847 is_member
/inc/functions_post.php 416 purgespammer_show
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "profilefield" - Line: 5 - File: inc/functions_post.php(484) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(484) : eval()'d code 5 errorHandler->error
/inc/functions_post.php 484 eval
/showthread.php 1114 build_postbit
Warning [2] Trying to access array offset on value of type null - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/url.php 1452 google_seo_tid
/inc/functions.php 6142 google_seo_url_post
/inc/functions_post.php 667 get_post_link
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "canonlyreplyownthreads" - Line: 672 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 672 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showimages" - Line: 757 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 757 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showvideos" - Line: 762 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 762 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showimages" - Line: 800 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 800 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 1535 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined variable $r1comma - Line: 491 - File: inc/plugins/thx.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php 491 errorHandler->error
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined variable $entries - Line: 491 - File: inc/plugins/thx.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php 491 errorHandler->error
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 1648 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 1742 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3524 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 7339 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "thxdsp_outline" - Line: 1 - File: inc/plugins/thx.php(342) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php(342) : eval()'d code 1 errorHandler->error
/inc/plugins/thx.php 342 eval
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2 - Line: 89 - File: inc/plugins/phptpl.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/phptpl.php 89 errorHandler->error
[PHP]   {closure}
/inc/plugins/phptpl.php 87 preg_replace_callback_array
/inc/plugins/phptpl.php(70) : eval()'d code 19 phptpl_parsetpl
/inc/functions_post.php 887 phptpl_templates->get
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "newpoints_postbit" - Line: 27 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 27 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "tyl_display" - Line: 52 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 52 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "thankyoulike_data" - Line: 52 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 52 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "button_tyl" - Line: 57 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 57 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "thanks" - Line: 57 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 57 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "canonlyviewownthreads" - Line: 1125 - File: showthread.php PHP 8.2.4 (Linux)
File Line Function
/showthread.php 1125 errorHandler->error
Warning [2] Undefined array key 516 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions.php 6046 get_profile_link
/showthread.php 1179 build_profile_link
Warning [2] Undefined array key 5528 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1412 google_seo_url_cache
/inc/functions.php 6093 google_seo_url_thread
/showthread.php 1194 get_thread_link
Warning [2] Undefined array key 17417 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions.php 6046 get_profile_link
/showthread.php 1208 build_profile_link
Warning [2] Undefined array key "threadprefix" - Line: 4 - File: showthread.php(1212) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/showthread.php(1212) : eval()'d code 4 errorHandler->error
/showthread.php 1212 eval
Warning [2] Undefined array key 3 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions.php 6046 get_profile_link
/showthread.php 1179 build_profile_link
Warning [2] Undefined array key 9606 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1412 google_seo_url_cache
/inc/functions.php 6093 google_seo_url_thread
/showthread.php 1194 get_thread_link
Warning [2] Undefined array key 13919 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions.php 6046 get_profile_link
/showthread.php 1208 build_profile_link
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کشف جدید در مورد چگونگی آسیب سلولی در بیماری ام اس
#1

محققین در دانشگاه آلبرتا موفق به کشف موضوعی شده اند که احتمالاً در آینده اساس درمانهای موفقی در این بیماری خواهد شد.

در هر بیماری التهابی از جمله بیماری ام اس، وقتی سلولهای ایمنی فعال میشوند، از سد خونی – مایع مغزی نخاعی عبور می کنند و وارد سیستم عصبی میشوند، در ام اس بعضی از این سلولهای ایمنی فعال شده، مولکولی ترشح می کنند به نام گرانزیم B (granzym B( این مولکول وارد سلول عصبی میشود و نهایتاً سبب مرگ سلول می شود .(لازم به توضیح است که این مولکول در مغز بیماران ام اس یافت شده است ). مولکول گرانزیم B، خود از طریق یک گیرنده به نام گیرنده M6PR قادر است وارد سلول عصبی شود. بنابراین از نظر تئوری اگر بتوان جلوی ورود این مولکول را بداخل سلول گرفت، احتمالاً خواهیم توانست از آسیب های سلولی جلوگیری کنیم. جلوگیری از آسیب های سلولی در فاز اول بیماری (فاز التهابی )، از میزان ناتوانی ها در فاز دوم بیماری می کاهد.

محققین برآنند که داروهایی بسازند که بتواند این امر را تحقق بخشد. از آنجا که این داروها فقط بر روی یک عمل سلولی بطور اختصاصی عمل می کنند. احتمالاً عوارض کمتری را به بیمار تحمیل خواهند کرد.

به امید موفقیت هر چه بیشتر


منبع:


WWW.medicalnewstoday.com
Published in Journal Of 1mmunology

سه شنبه 10 آبان 1390

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