اخطار‌های زیر رخ داد:
Warning [2] Undefined array key "extra" - Line: 100 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 100 errorHandler->error
/inc/plugins/google_seo.php 317 require_once
/inc/class_plugins.php 38 require_once
/inc/init.php 239 pluginSystem->load
/global.php 20 require_once
/showthread.php 28 require_once
Warning [2] Undefined array key "parent" - Line: 447 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 447 errorHandler->error
/inc/plugins/google_seo/url.php 1144 google_seo_url_create
/inc/plugins/google_seo/url.php 174 google_seo_url_hook
/inc/plugins/google_seo.php 317 require_once
/inc/class_plugins.php 38 require_once
/inc/init.php 239 pluginSystem->load
/global.php 20 require_once
/showthread.php 28 require_once
Warning [2] Undefined array key "lockoutexpiry" - Line: 94 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 94 errorHandler->error
/showthread.php 28 require_once
Warning [2] Trying to access array offset on value of type null - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/redirect.php 131 google_seo_tid
/inc/class_plugins.php 142 google_seo_redirect_hook
/global.php 100 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined array key 284690 - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/url.php 1452 google_seo_tid
/inc/functions.php 6142 google_seo_url_post
/inc/plugins/google_seo/redirect.php 134 get_post_link
/inc/class_plugins.php 142 google_seo_redirect_hook
/global.php 100 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Constant IN_MYBB already defined - Line: 9 - File: affiliate.php PHP 8.2.4 (Linux)
File Line Function
[PHP]   errorHandler->error
/affiliate.php 9 define
/global.php 102 require_once
/showthread.php 28 require_once
Warning [2] Undefined variable $affiliate - Line: 44 - File: affiliate.php PHP 8.2.4 (Linux)
File Line Function
/affiliate.php 44 errorHandler->error
/global.php 102 require_once
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$today_rel - Line: 474 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 474 errorHandler->error
/global.php 476 my_date
/showthread.php 28 require_once
Warning [2] Undefined array key "lockoutexpiry" - Line: 555 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 555 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined array key "avatartype" - Line: 816 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 816 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined array key "avatartype" - Line: 816 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 816 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined variable $myalerts_js - Line: 104 - File: global.php(874) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(874) : eval()'d code 104 errorHandler->error
/global.php 874 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $awaitingusers - Line: 495 - File: global.php(877) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(877) : eval()'d code 495 errorHandler->error
/global.php 877 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $bam_announcements - Line: 497 - File: global.php(877) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(877) : eval()'d code 497 errorHandler->error
/global.php 877 eval
/showthread.php 28 require_once
Warning [2] Undefined array key "style" - Line: 942 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 942 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$lang_select_default - Line: 5211 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 5211 errorHandler->error
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_google_plus - Line: 18 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 18 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_facebook - Line: 19 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 19 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_twitter - Line: 20 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 20 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_pinterest - Line: 21 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 21 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $myalerts_modal - Line: 61 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 61 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $choosekq - Line: 785 - File: inc/plugins/changstats.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php 785 errorHandler->error
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $listtab - Line: 800 - File: inc/plugins/changstats.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php 800 errorHandler->error
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $chooselatestposts - Line: 3 - File: inc/plugins/changstats.php(801) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(801) : eval()'d code 3 errorHandler->error
/inc/plugins/changstats.php 801 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $choosetop_user - Line: 4 - File: inc/plugins/changstats.php(823) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(823) : eval()'d code 4 errorHandler->error
/inc/plugins/changstats.php 823 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $choosetop_forum - Line: 4 - File: inc/plugins/changstats.php(824) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(824) : eval()'d code 4 errorHandler->error
/inc/plugins/changstats.php 824 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $autorefresh - Line: 73 - File: inc/plugins/changstats.php(842) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(842) : eval()'d code 73 errorHandler->error
/inc/plugins/changstats.php 842 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined array key 3 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4486 get_forum_link
/inc/functions.php 4458 build_forum_breadcrumb
/inc/functions.php 4458 build_forum_breadcrumb
/showthread.php 454 build_forum_breadcrumb
Warning [2] Trying to access array offset on value of type null - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4486 get_forum_link
/inc/functions.php 4458 build_forum_breadcrumb
/inc/functions.php 4458 build_forum_breadcrumb
/showthread.php 454 build_forum_breadcrumb
Warning [2] Undefined array key 17 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4486 get_forum_link
/inc/functions.php 4458 build_forum_breadcrumb
/showthread.php 454 build_forum_breadcrumb
Warning [2] Undefined array key 19 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4479 get_forum_link
/showthread.php 454 build_forum_breadcrumb
Warning [2] Trying to access array offset on value of type null - Line: 488 - File: inc/db_mysqli.php PHP 8.2.4 (Linux)
File Line Function
/inc/db_mysqli.php 488 errorHandler->error
/showthread.php 758 DB_MySQLi->fetch_field
Warning [2] Undefined property: MyLanguage::$ratings_update_error - Line: 5 - File: showthread.php(768) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/showthread.php(768) : eval()'d code 5 errorHandler->error
/showthread.php 768 eval
Warning [2] Undefined array key 1 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions_post.php 251 get_profile_link
/showthread.php 1114 build_postbit
Warning [2] Trying to access array offset on value of type null - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions_post.php 251 get_profile_link
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions_user.php 847 is_member
/inc/functions_post.php 416 purgespammer_show
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "profilefield" - Line: 5 - File: inc/functions_post.php(484) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(484) : eval()'d code 5 errorHandler->error
/inc/functions_post.php 484 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 282561 - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/url.php 1452 google_seo_tid
/inc/functions.php 6142 google_seo_url_post
/inc/functions_post.php 667 get_post_link
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "canonlyreplyownthreads" - Line: 672 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 672 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showimages" - Line: 757 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 757 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showvideos" - Line: 762 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 762 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3524 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined variable $r1comma - Line: 491 - File: inc/plugins/thx.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php 491 errorHandler->error
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined variable $entries - Line: 491 - File: inc/plugins/thx.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php 491 errorHandler->error
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3328 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 1857 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3906 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2400 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 723 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "thxdsp_outline" - Line: 1 - File: inc/plugins/thx.php(342) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php(342) : eval()'d code 1 errorHandler->error
/inc/plugins/thx.php 342 eval
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2 - Line: 89 - File: inc/plugins/phptpl.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/phptpl.php 89 errorHandler->error
[PHP]   {closure}
/inc/plugins/phptpl.php 87 preg_replace_callback_array
/inc/plugins/phptpl.php(70) : eval()'d code 19 phptpl_parsetpl
/inc/functions_post.php 887 phptpl_templates->get
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "newpoints_postbit" - Line: 27 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 27 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "tyl_display" - Line: 52 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 52 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "thankyoulike_data" - Line: 52 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 52 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "button_tyl" - Line: 57 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 57 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "thanks" - Line: 57 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 57 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3430 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions_post.php 251 get_profile_link
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions_user.php 847 is_member
/inc/functions_post.php 416 purgespammer_show
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "profilefield" - Line: 5 - File: inc/functions_post.php(484) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(484) : eval()'d code 5 errorHandler->error
/inc/functions_post.php 484 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 284644 - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/url.php 1452 google_seo_tid
/inc/functions.php 6142 google_seo_url_post
/inc/functions_post.php 667 get_post_link
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "canonlyreplyownthreads" - Line: 672 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 672 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showimages" - Line: 757 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 757 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showvideos" - Line: 762 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 762 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showimages" - Line: 800 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 800 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2303 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
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شناسایی سلول های ایمنی جدید موثر در MS
#1


یک نوع خاص از سلول سیستم ایمنی بدن، به نام Tc17، در محل ضایعات MS در انسان یافت شده است، اما معلوم نیست چه نقشی این سلول ها در پاتوژنز بیماری بازی می کنند. در تحقیقی که در مجله تحقیقات بالینی توسط ماگدالنا هوبر در دانشگاه ماربورگ در آلمان منتشر شده است، با استفاده از ام اس مدل موش به تعیین نقش Tc17 پرداخته است.

آنها دریافتند که سلولهای Tc17 به سلولهای ایمنی Th17 کمک می کنند تا به سیستم عصبی مرکزی با ترشح پروتئین IL-17 حمله کنند. بدون سلول Tc17 ، سلول Th17 در سیستم مرکزی عصبی نمی تواند تجمع کند،بنابراین از توسعه MS جلوگیری به عمل می آید.

این مطالعه نشان می دهد، که سلول Tc17 به آغاز MS ا با اجازه دادن به سلول های ایمنی برای رسیدن به سیستم عصبی مرکزی کمک می کند و نشان می دهد که درمان با هدف قرار دادن Tc17 در درمان اولیه MS ممکن است مفید باشند

Source: Science Codex (02/01/13)

 تشکر شده توسط : sargol , mysis , n.gh , sib , zohrevand , عمومهربان
#2
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« کشف سلولهای ایمنی آغازگر بیماری ام اس ... »
20 دی 1391

یکی از مشخصات بیماری ام اس ، تزاید و تجمع سلولهای ایمنی در سیستم عصبی است . نوع بخصوصی از سلولهای ایمنی بنام Tc17 ، پیش از این در ضایعات ام اس یافت شده بود، اما بدرستی مشخص نبود که این سلولها چه نقشی را در بیماری بازی می کنند.

اخیراً مطالعه ای در دانشگاه Marburg آلمان بر روی موش ها انجام گرفته تا نقش این سلولها را در بیماری ام اس مشخص نماید. بر اساس نتایج این تحقیق به نظر می رسد سلولهای Tc17 ، نوع دیگری از سلولهای ایمنی را بنام ( Th17 ) تحریک می کند تا به سیستم عصبی حمله ور شوند. ( با واسطه پروتئینی بنامIL17 ) بطوریکه بدون وجود سلولهای Tc17، دیگر سلولهای Th17 قادر به تجمع در سیستم عصبی نیستند.
این مطالعه نشان میدهد که سلولهای Tc17 احتمالاً آغازگر روند التهابی در ام اس هستند ( یا به آن کمک می کنند) و لذا می توانند هدف خوبی برای اقدامات درمانی جدید باشند.

منبع انجمن ام اس ایران
ﭼﻘﺪﺭ ﺩﻭﺳﺖ ﺩﺍﺷﺘﻨﯽ ﻫﺴﺘﻨﺪ٬ ﺁﺩﻣﻬﺎﯾﯽ ﮐﻪ ﺷﺒﯿﻪ ﺣﺮﻓﻬﺎﯾﺸﺎﻥ ﻫﺴﺘﻨﺪ...
 تشکر شده توسط : paeazan , zohrevand , MFhealth , آسو , عمومهربان
  


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