اخطار‌های زیر رخ داد:
Warning [2] Undefined array key "extra" - Line: 100 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 100 errorHandler->error
/inc/plugins/google_seo.php 317 require_once
/inc/class_plugins.php 38 require_once
/inc/init.php 239 pluginSystem->load
/global.php 20 require_once
/showthread.php 28 require_once
Warning [2] Undefined array key "parent" - Line: 447 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 447 errorHandler->error
/inc/plugins/google_seo/url.php 1144 google_seo_url_create
/inc/plugins/google_seo/url.php 174 google_seo_url_hook
/inc/plugins/google_seo.php 317 require_once
/inc/class_plugins.php 38 require_once
/inc/init.php 239 pluginSystem->load
/global.php 20 require_once
/showthread.php 28 require_once
Warning [2] Trying to access array offset on value of type null - Line: 59 - File: inc/class_session.php PHP 8.2.4 (Linux)
File Line Function
/inc/class_session.php 59 errorHandler->error
/global.php 49 session->init
/showthread.php 28 require_once
Warning [2] Undefined array key "lockoutexpiry" - Line: 94 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 94 errorHandler->error
/showthread.php 28 require_once
Warning [2] Trying to access array offset on value of type null - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/redirect.php 131 google_seo_tid
/inc/class_plugins.php 142 google_seo_redirect_hook
/global.php 100 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined array key 541727 - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/url.php 1452 google_seo_tid
/inc/functions.php 6142 google_seo_url_post
/inc/plugins/google_seo/redirect.php 134 get_post_link
/inc/class_plugins.php 142 google_seo_redirect_hook
/global.php 100 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Constant IN_MYBB already defined - Line: 9 - File: affiliate.php PHP 8.2.4 (Linux)
File Line Function
[PHP]   errorHandler->error
/affiliate.php 9 define
/global.php 102 require_once
/showthread.php 28 require_once
Warning [2] Undefined variable $affiliate - Line: 44 - File: affiliate.php PHP 8.2.4 (Linux)
File Line Function
/affiliate.php 44 errorHandler->error
/global.php 102 require_once
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$today_rel - Line: 474 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 474 errorHandler->error
/global.php 476 my_date
/showthread.php 28 require_once
Warning [2] Undefined array key "lockoutexpiry" - Line: 555 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 555 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined array key "avatartype" - Line: 816 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 816 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined array key "avatartype" - Line: 816 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 816 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined variable $myalerts_js - Line: 104 - File: global.php(874) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(874) : eval()'d code 104 errorHandler->error
/global.php 874 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $awaitingusers - Line: 495 - File: global.php(877) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(877) : eval()'d code 495 errorHandler->error
/global.php 877 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $bam_announcements - Line: 497 - File: global.php(877) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(877) : eval()'d code 497 errorHandler->error
/global.php 877 eval
/showthread.php 28 require_once
Warning [2] Undefined array key "style" - Line: 942 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 942 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$lang_select_default - Line: 5211 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 5211 errorHandler->error
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_google_plus - Line: 18 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 18 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_facebook - Line: 19 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 19 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_twitter - Line: 20 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 20 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_pinterest - Line: 21 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 21 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $myalerts_modal - Line: 61 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 61 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $choosekq - Line: 785 - File: inc/plugins/changstats.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php 785 errorHandler->error
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $listtab - Line: 800 - File: inc/plugins/changstats.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php 800 errorHandler->error
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $chooselatestposts - Line: 3 - File: inc/plugins/changstats.php(801) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(801) : eval()'d code 3 errorHandler->error
/inc/plugins/changstats.php 801 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $choosetop_user - Line: 4 - File: inc/plugins/changstats.php(823) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(823) : eval()'d code 4 errorHandler->error
/inc/plugins/changstats.php 823 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $choosetop_forum - Line: 4 - File: inc/plugins/changstats.php(824) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(824) : eval()'d code 4 errorHandler->error
/inc/plugins/changstats.php 824 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $autorefresh - Line: 73 - File: inc/plugins/changstats.php(842) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(842) : eval()'d code 73 errorHandler->error
/inc/plugins/changstats.php 842 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined array key 3 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4486 get_forum_link
/inc/functions.php 4458 build_forum_breadcrumb
/showthread.php 454 build_forum_breadcrumb
Warning [2] Trying to access array offset on value of type null - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4486 get_forum_link
/inc/functions.php 4458 build_forum_breadcrumb
/showthread.php 454 build_forum_breadcrumb
Warning [2] Undefined array key 17 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4479 get_forum_link
/showthread.php 454 build_forum_breadcrumb
Warning [2] Undefined property: MyLanguage::$ratings_update_error - Line: 5 - File: showthread.php(768) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/showthread.php(768) : eval()'d code 5 errorHandler->error
/showthread.php 768 eval
Warning [2] Undefined array key 1 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions_post.php 251 get_profile_link
/showthread.php 1114 build_postbit
Warning [2] Trying to access array offset on value of type null - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions_post.php 251 get_profile_link
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions_user.php 847 is_member
/inc/functions_post.php 416 purgespammer_show
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "profilefield" - Line: 5 - File: inc/functions_post.php(484) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(484) : eval()'d code 5 errorHandler->error
/inc/functions_post.php 484 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 541622 - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/url.php 1452 google_seo_tid
/inc/functions.php 6142 google_seo_url_post
/inc/functions_post.php 667 get_post_link
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "canonlyreplyownthreads" - Line: 672 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 672 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showimages" - Line: 757 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 757 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showvideos" - Line: 762 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 762 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 8087 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined variable $r1comma - Line: 491 - File: inc/plugins/thx.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php 491 errorHandler->error
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined variable $entries - Line: 491 - File: inc/plugins/thx.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php 491 errorHandler->error
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 8251 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 408 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 8771 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 98 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2400 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 723 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "thxdsp_outline" - Line: 1 - File: inc/plugins/thx.php(342) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php(342) : eval()'d code 1 errorHandler->error
/inc/plugins/thx.php 342 eval
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2 - Line: 89 - File: inc/plugins/phptpl.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/phptpl.php 89 errorHandler->error
[PHP]   {closure}
/inc/plugins/phptpl.php 87 preg_replace_callback_array
/inc/plugins/phptpl.php(70) : eval()'d code 19 phptpl_parsetpl
/inc/functions_post.php 887 phptpl_templates->get
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "newpoints_postbit" - Line: 27 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 27 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "tyl_display" - Line: 52 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 52 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "thankyoulike_data" - Line: 52 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 52 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "button_tyl" - Line: 57 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 57 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "thanks" - Line: 57 - File: inc/functions_post.php(887) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(887) : eval()'d code 57 errorHandler->error
/inc/functions_post.php 887 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "canonlyviewownthreads" - Line: 1125 - File: showthread.php PHP 8.2.4 (Linux)
File Line Function
/showthread.php 1125 errorHandler->error
Warning [2] Undefined array key 108 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions.php 6046 get_profile_link
/showthread.php 1179 build_profile_link
Warning [2] Undefined array key 10791 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1412 google_seo_url_cache
/inc/functions.php 6093 google_seo_url_thread
/showthread.php 1194 get_thread_link
Warning [2] Undefined array key "threadprefix" - Line: 4 - File: showthread.php(1212) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/showthread.php(1212) : eval()'d code 4 errorHandler->error
/showthread.php 1212 eval
Warning [2] Undefined array key 17 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions.php 6046 get_profile_link
/showthread.php 1179 build_profile_link
Warning [2] Undefined array key 6411 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1412 google_seo_url_cache
/inc/functions.php 6093 google_seo_url_thread
/showthread.php 1194 get_thread_link
Warning [2] Undefined array key "threadprefix" - Line: 4 - File: showthread.php(1212) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/showthread.php(1212) : eval()'d code 4 errorHandler->error
/showthread.php 1212 eval
Warning [2] Undefined array key 12032 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1412 google_seo_url_cache
/inc/functions.php 6093 google_seo_url_thread
/showthread.php 1194 get_thread_link
Warning [2] Undefined array key "threadprefix" - Line: 4 - File: showthread.php(1212) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/showthread.php(1212) : eval()'d code 4 errorHandler->error
/showthread.php 1212 eval
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پیوند سلول های بنیادی ممکن است موجب بهبودی طولانی مدت MS شود
#1
نتایج یک مطالعه بالینی جدید، شواهدی را ارائه می کند که استفاده از داروهای سرکوب کننده ایمنی با دوز بسیار بالا و به دنبال آن پیوند سلول های بنیادی خون ساز مشتق از خود فرد می تواند موجب بهبودی طولانی مدت فرد مبتلا به مولتیپل اسکلروزیس(MS) شود.

به گزارش بنیان به نقل از medicalxpress، در مطالعه ای بالینی تحت عنوان HALT-MS که تحت حمایت مالی انستیتو ملی آلرژی و بیماری های عفونی(NIAID) بود و پنج سال طول کشید، محققین نشان دادند که 69 درصد از بیماران مبتلا به MS‌که مورد تیمار با دوز بالای داروهای سرکوب کننده ایمنی و به دنبال آن پیوند سلول های بنیادی خون ساز اتولوگ(HDIT/HCT) قرار گرفتند، بدون این که ناتوانی پیشرونده ای را تجربه کنند و علایم MS‌در آن ها مجددا عود کند یا آسیب های مغزی جدیدی در آن ها ایجاد شود، زنده ماندند. نکته جالب توجه این درمان این بود که هیچ کدام از این بیماران بعد از تیمار HDIT/HCT‌نیازمند مصرف داروهای MS‌نبودند. این در حالی است که سایر مطالعات صورت گرفته نشان داده است که استفاده از داروهای MS، این میزان موفقیت را ندارند. این مطالعه جالب نشان می دهد که یک بار استفاده از HDIT/HCT می تواند به طور قابل ملاحظه ای موثرتر از درمان های طولانی مدت بوسیله بهترین داروهای MS‌باشد. این یافته های ترغیب کننده موجب شده است که محققین بدنبال بهبود استفاده از این روش درمانی(استفاده از داروهای سرکوب کننده دوز بالا و پیوند سلول های بنیادی) و ارائه آن به عنوان درمانی استاندارد برای افراد مبتلا به MS باشد.

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 تشکر شده توسط : niloofary , mojtabasalimi28 , montazer , Ata1988 , aztab , zohrevand , عمومهربان
  


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