اخطار‌های زیر رخ داد:
Warning [2] Undefined array key "extra" - Line: 100 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 100 errorHandler->error
/inc/plugins/google_seo.php 317 require_once
/inc/class_plugins.php 38 require_once
/inc/init.php 239 pluginSystem->load
/global.php 20 require_once
/showthread.php 28 require_once
Warning [2] Undefined array key "parent" - Line: 447 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 447 errorHandler->error
/inc/plugins/google_seo/url.php 1144 google_seo_url_create
/inc/plugins/google_seo/url.php 174 google_seo_url_hook
/inc/plugins/google_seo.php 317 require_once
/inc/class_plugins.php 38 require_once
/inc/init.php 239 pluginSystem->load
/global.php 20 require_once
/showthread.php 28 require_once
Warning [2] Trying to access array offset on value of type null - Line: 59 - File: inc/class_session.php PHP 8.2.4 (Linux)
File Line Function
/inc/class_session.php 59 errorHandler->error
/global.php 49 session->init
/showthread.php 28 require_once
Warning [2] Undefined array key "lockoutexpiry" - Line: 94 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 94 errorHandler->error
/showthread.php 28 require_once
Warning [2] Trying to access array offset on value of type null - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/redirect.php 131 google_seo_tid
/inc/class_plugins.php 142 google_seo_redirect_hook
/global.php 100 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined array key 245700 - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/url.php 1452 google_seo_tid
/inc/functions.php 6142 google_seo_url_post
/inc/plugins/google_seo/redirect.php 134 get_post_link
/inc/class_plugins.php 142 google_seo_redirect_hook
/global.php 100 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Constant IN_MYBB already defined - Line: 9 - File: affiliate.php PHP 8.2.4 (Linux)
File Line Function
[PHP]   errorHandler->error
/affiliate.php 9 define
/global.php 102 require_once
/showthread.php 28 require_once
Warning [2] Undefined variable $affiliate - Line: 44 - File: affiliate.php PHP 8.2.4 (Linux)
File Line Function
/affiliate.php 44 errorHandler->error
/global.php 102 require_once
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$today_rel - Line: 474 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 474 errorHandler->error
/global.php 476 my_date
/showthread.php 28 require_once
Warning [2] Undefined array key "lockoutexpiry" - Line: 555 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 555 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined array key "avatartype" - Line: 816 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 816 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined array key "avatartype" - Line: 816 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 816 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined variable $myalerts_js - Line: 104 - File: global.php(874) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(874) : eval()'d code 104 errorHandler->error
/global.php 874 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $awaitingusers - Line: 495 - File: global.php(877) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(877) : eval()'d code 495 errorHandler->error
/global.php 877 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $bam_announcements - Line: 497 - File: global.php(877) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(877) : eval()'d code 497 errorHandler->error
/global.php 877 eval
/showthread.php 28 require_once
Warning [2] Undefined array key "style" - Line: 942 - File: global.php PHP 8.2.4 (Linux)
File Line Function
/global.php 942 errorHandler->error
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$lang_select_default - Line: 5211 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 5211 errorHandler->error
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions.php 5231 is_member
/global.php 942 build_theme_select
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_google_plus - Line: 18 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 18 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_facebook - Line: 19 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 19 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_twitter - Line: 20 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 20 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined property: MyLanguage::$hrz_like_us_pinterest - Line: 21 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 21 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $myalerts_modal - Line: 61 - File: global.php(971) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/global.php(971) : eval()'d code 61 errorHandler->error
/global.php 971 eval
/showthread.php 28 require_once
Warning [2] Undefined variable $choosekq - Line: 785 - File: inc/plugins/changstats.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php 785 errorHandler->error
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $listtab - Line: 800 - File: inc/plugins/changstats.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php 800 errorHandler->error
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $chooselatestposts - Line: 3 - File: inc/plugins/changstats.php(801) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(801) : eval()'d code 3 errorHandler->error
/inc/plugins/changstats.php 801 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $choosetop_user - Line: 4 - File: inc/plugins/changstats.php(823) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(823) : eval()'d code 4 errorHandler->error
/inc/plugins/changstats.php 823 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $choosetop_forum - Line: 4 - File: inc/plugins/changstats.php(824) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(824) : eval()'d code 4 errorHandler->error
/inc/plugins/changstats.php 824 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined variable $autorefresh - Line: 73 - File: inc/plugins/changstats.php(842) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/changstats.php(842) : eval()'d code 73 errorHandler->error
/inc/plugins/changstats.php 842 eval
/inc/class_plugins.php 142 changstats_maindisplay
/global.php 1165 pluginSystem->run_hooks
/showthread.php 28 require_once
Warning [2] Undefined array key 3 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4486 get_forum_link
/inc/functions.php 4458 build_forum_breadcrumb
/inc/functions.php 4458 build_forum_breadcrumb
/showthread.php 454 build_forum_breadcrumb
Warning [2] Trying to access array offset on value of type null - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4486 get_forum_link
/inc/functions.php 4458 build_forum_breadcrumb
/inc/functions.php 4458 build_forum_breadcrumb
/showthread.php 454 build_forum_breadcrumb
Warning [2] Undefined array key 17 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4486 get_forum_link
/inc/functions.php 4458 build_forum_breadcrumb
/showthread.php 454 build_forum_breadcrumb
Warning [2] Undefined array key 19 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1381 google_seo_url_cache
/inc/functions.php 6061 google_seo_url_forum
/inc/functions.php 4479 get_forum_link
/showthread.php 454 build_forum_breadcrumb
Warning [2] Trying to access array offset on value of type null - Line: 488 - File: inc/db_mysqli.php PHP 8.2.4 (Linux)
File Line Function
/inc/db_mysqli.php 488 errorHandler->error
/showthread.php 758 DB_MySQLi->fetch_field
Warning [2] Undefined property: MyLanguage::$ratings_update_error - Line: 5 - File: showthread.php(768) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/showthread.php(768) : eval()'d code 5 errorHandler->error
/showthread.php 768 eval
Warning [2] Undefined array key 1 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions_post.php 251 get_profile_link
/showthread.php 1114 build_postbit
Warning [2] Trying to access array offset on value of type null - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/functions_post.php 251 get_profile_link
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "additionalgroups" - Line: 7447 - File: inc/functions.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions.php 7447 errorHandler->error
/inc/functions_user.php 847 is_member
/inc/functions_post.php 416 purgespammer_show
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "profilefield" - Line: 5 - File: inc/functions_post.php(484) : eval()'d code PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php(484) : eval()'d code 5 errorHandler->error
/inc/functions_post.php 484 eval
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 245700 - Line: 198 - File: inc/plugins/google_seo.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo.php 198 errorHandler->error
/inc/plugins/google_seo/url.php 1452 google_seo_tid
/inc/functions.php 6142 google_seo_url_post
/inc/functions_post.php 667 get_post_link
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "canonlyreplyownthreads" - Line: 672 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 672 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showimages" - Line: 757 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 757 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key "showvideos" - Line: 762 - File: inc/functions_post.php PHP 8.2.4 (Linux)
File Line Function
/inc/functions_post.php 762 errorHandler->error
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 1030 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined variable $r1comma - Line: 491 - File: inc/plugins/thx.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php 491 errorHandler->error
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined variable $entries - Line: 491 - File: inc/plugins/thx.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/thx.php 491 errorHandler->error
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3229 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3084 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2784 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2303 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 1535 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 1289 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3662 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2867 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 1834 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2272 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3756 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 2400 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3055 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
Warning [2] Undefined array key 3302 - Line: 833 - File: inc/plugins/google_seo/url.php PHP 8.2.4 (Linux)
File Line Function
/inc/plugins/google_seo/url.php 833 errorHandler->error
/inc/plugins/google_seo/url.php 1347 google_seo_url_cache
/inc/functions.php 5978 google_seo_url_profile
/inc/plugins/thx.php 484 get_profile_link
/inc/plugins/thx.php 303 build_thank
/inc/class_plugins.php 142 thx
/inc/functions_post.php 842 pluginSystem->run_hooks
/showthread.php 1114 build_postbit
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چگونه ام اس پیشرفت می کند؟ سرنخ احتمالی کشف شد!!
#1
محققان کشف کرده اند که یک یا چند ماده تولید شده توسط یک نوع خاصی از سلول های ایمنی بدن ممکن است در پیشرفت بیماری ام اس موثر باشد. پیدا کردن این موضوع می تواند به درمان های جدید و هدفمند برای افراد مبتلا به MS منجر شود. سلول های B به یک زیر مجموعه از سلول های سفید خون (لنفوسیتها) تعلق دارند که تبدیل به ایمونوگلوبولین (آنتی بادی) در تولید سلول های پلاسما در زمانی که بالغ هستند می شوند. با این حال، سلول های B به نظر می رسد که در کنترل لنفوسیت های دیگر، به خصوص سلول های T، و کمک به تنظیم سیستم ایمنی سالم نقش دارند.حمله سلول های B در مغز و طناب نخاعی در بیماران مبتلا به MS، با توجه به این واقعیت است که سیستم عصبی و مننژ، پوشش مغز و نخاع، موادی را تولید می کند که سلول های B را جذب می کند. هنگامی که در داخل مننژ یا سیستم عصبی مرکزی، سلول های B جذب وفعال شدند یک یا چند ماده را ترشح می کنند که به الیگودندروسیتها ( سلولهای تولید کننده غلاف میلین ) آسیب می زنند، در عین حال که به نظر نمی رسد ایمونوگلوبولینها را تحت تاثیر قرار داده باشد. دانشمندان مشاهده کردند که سلول های B به نظر می رسد در بیماران مبتلا به MS فعال تر هستند. این مسئله می تواند توضیح دهد که چرا این سلول ها تولید مواد سمی می کنند و چرا توسط سیستم عصبی و مننژ جلب و جذب می شوند.
در این مطالعه، گروه تحقیق سلول های B از خون 7 بیمار مبتلا به MS عود کننده فروکش کننده و از 4 نفر سالم را دریافت کردند. پژوهشگران سپس سلولها را در یک ظرف مخصوص جمع آوری کرده و مواد تولید شده را پس از از بین بردن آنها استخراج کردند.آنها سپس مواد تولید شده را به سلولها ی تولید کننده میلین در مدل های حیوانی تزریق کردند. آنها کشف کردند که بطور قابل توجهی تعداد بیشتری از الیگودندروسیتها در گروه MS در مقایسه با مواد تولید شده توسط سلول های B از افراد سالم می میرند. این یافته بسیار مهم است، به خصوص برای صدمه به قشر مغزی در بیماران مبتلا به MS ، زیرا این مناطق به نظر می رسد با گسترش مواد به مغز از مننژ، که غنی از سلول های B است، آسیب می بیند. "این تیم در حال برنامه ریزی برای ادامه تحقیق خود است که این به طور بالقوه می تواند منجر به درمانهای جدیدی شود که می تواند باعث خاموش شدن مرگ الیگودندروسایتها توسط سلول های B و در نتیجه کمک به محافظت از میلین شود.

http://www.medicalnewstoday.com/articles/248678.php
 تشکر شده توسط : ehsan 10054 , aazz , آیدا , reihane , paeazan , najva , AVID2000 , TELECOM , زهراجون , ارزو , niko , زرشک , zohrevand , sooorooosh , ابراهیم
  


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